Libyan Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 5  |  Issue : 1  |  Page : 6--10

Effect of renin-angiotensin-aldosterone system blockade on intestinal injury induced by indomethacin in rats


Asmaa Abdulaziz A. Rabee1, Yahya Saber E. Mansour2, Huda A Mariz3, Salwa Muftah Eljamay4 
1 Department of Pharmacology, Faculty of Medicine, Omar Elmokhtar University, Derna, Libya
2 Department of Pharmacy and Toxicology, Faculty of Pharmacy, Omar Elmokhtar University, Elbieda, Libya
3 Department of Pharmaceutical Technology, College of Medical Technology, Derna, Libya
4 Department of Public Health Technology, College of Medical Technology, Derna, Libya

Correspondence Address:
Dr. Salwa Muftah Eljamay
Department of Public Health Technology, College of Medical Technology, Derna
Libya

Aim: The aim of this experimental study was to evaluate the possible cytoprotective effects of renin-angiotensin-aldosterone system (RAAS) blockade, captopril (10 mg/kg), telmisartan (10 mg/kg), and a proton-pump inhibitor (lansoprazole) on intestinal injury induced by indomethacin in rats. Materials and Methods: This effect was evaluated through the assessment of intestinal inflammatory biomarkers and oxidative stress parameters. Forty adult male albino rats weighing 170–200 g were used and divided equally into five groups. After the treatment, the following were assessed: Myeloperoxidase (MPO) enzyme activity, pro-inflammatory (interleukin-1beta [IL-1 β]) content and anti-inflammatory (IL-10) content, malondialdehyde (MDA) content, reduced glutathione (GSH) content, and superoxide dismutase (SOD) enzyme activity, and histopathological examination of the intestinal tissues was conducted. Results: Indomethacin group induced a significant increase in MDA content, also in inflammatory biomarker (MPO enzyme activity, IL-1 β content, and IL-10 content) compared to normal control, while indomethacin group induced a significant decrease in GSH content, SOD enzyme activity compared to normal control group. Captopril, telmisartan, lansoprazole administration before indomethacin-induced significant increase in GSH content, SOD enzyme activity, while induced significant decrease in MDA content as well as in inflammatory biomarker compared to indomethacin group, which indicate the antioxidant, anti-inflammatory effects, and the gastroprotective properties of RAAS blockers, which also shown in the histopathological examination of intestinal tissues. Conclusion: This study showed the possible antioxidant and anti-inflammatory effects as well as the gastroprotective properties of RAAS blockers. Telmisartan has more antioxidant and anti-inflammatory effect as well as cytoprotective action than captopril.


How to cite this article:
A. Rabee AA, E. Mansour YS, Mariz HA, Eljamay SM. Effect of renin-angiotensin-aldosterone system blockade on intestinal injury induced by indomethacin in rats.Libyan J Med Sci 2021;5:6-10


How to cite this URL:
A. Rabee AA, E. Mansour YS, Mariz HA, Eljamay SM. Effect of renin-angiotensin-aldosterone system blockade on intestinal injury induced by indomethacin in rats. Libyan J Med Sci [serial online] 2021 [cited 2021 Sep 27 ];5:6-10
Available from: https://www.ljmsonline.com/article.asp?issn=2588-9044;year=2021;volume=5;issue=1;spage=6;epage=10;aulast=A.;type=0