Libyan Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 4  |  Issue : 3  |  Page : 120--124

Association of serum midkine levels with insulin resistance and obesity in patients with polycystic ovarian syndrome


Fatma Beyazit1, Fatih Kamis2, Eren Pek1, Yavuz Beyazit2 
1 Department of Obstetrics and Gynecology, Faculty of Medicine, Çanakkale 18 Mart University, Çanakkale, Turkey
2 Department of Internal Medicine, Faculty of Medicine, Çanakkale 18 Mart University, Çanakkale, Turkey

Correspondence Address:
Dr. Eren Pek
Department of Obstetrics and Gynecology, Çanakkale 18 Mart University Hospital, Çanakkale
Turkey

Objectives: Polycystic ovarian syndrome (PCOS) is thought to be a subclinical inflammatory state with increased levels of circulating pro-inflammatory cytokines. Midkine is a pleiotropic heparin-binding neurotrophic factor with pro-inflammatory properties, and growing evidence has shown a substantial effect of midkine in inflammation. This study aimed to test whether midkine has a role in PCOS development and its relation to obesity and insulin resistance (IR). Materials and Methods: In this comparative cross-sectional study, 56 women with PCOS and 36 eumenorrheic nonhirsute, age- and body mass index (BMI)-matched women as the control group were recruited. Routine and specific (midkine) laboratory analysis and IR measurements were applied to both the study groups. Results: There were no statistically significant difference between PCOS patients and controls with regard to serum midkine levels (P = 0.412). PCOS patients were further divided into two subgroups according to BMI levels. Serum midkine levels were found to be increased in overweight PCOS patients compared with normal-weight PCOS patients (P = 0.044). Although an increasing trend was observed in respect to serum midkine levels in PCOS women with IR (Homeostatic Model Assessment-IR ≥2.5), this elevation was not statistically significant (P = 0.301). Conclusions: The positive effect of obesity on midkine levels supports the idea that midkine is probably released from adipocyte cells. IR possibly has an important role in this mechanism.


How to cite this article:
Beyazit F, Kamis F, Pek E, Beyazit Y. Association of serum midkine levels with insulin resistance and obesity in patients with polycystic ovarian syndrome.Libyan J Med Sci 2020;4:120-124


How to cite this URL:
Beyazit F, Kamis F, Pek E, Beyazit Y. Association of serum midkine levels with insulin resistance and obesity in patients with polycystic ovarian syndrome. Libyan J Med Sci [serial online] 2020 [cited 2022 Dec 8 ];4:120-124
Available from: https://www.ljmsonline.com/article.asp?issn=2588-9044;year=2020;volume=4;issue=3;spage=120;epage=124;aulast=Beyazit;type=0