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LETTER TO EDITOR
Year : 2020  |  Volume : 4  |  Issue : 3  |  Page : 155

A descriptive study of inflammatory bowel disease in eastern regions of Libya: A based survey of benghaziæs hospitals


Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

Date of Submission25-Jun-2020
Date of Acceptance06-Jul-2020
Date of Web Publication21-Sep-2020

Correspondence Address:
Prof. Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, P. O. Box 55302, Baghdad Post Office, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/LJMS.LJMS_55_20

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How to cite this article:
Al-Mendalawi MD. A descriptive study of inflammatory bowel disease in eastern regions of Libya: A based survey of benghaziæs hospitals. Libyan J Med Sci 2020;4:155

How to cite this URL:
Al-Mendalawi MD. A descriptive study of inflammatory bowel disease in eastern regions of Libya: A based survey of benghaziæs hospitals. Libyan J Med Sci [serial online] 2020 [cited 2020 Oct 20];4:155. Available from: https://www.ljmsonline.com/text.asp?2020/4/3/155/295616



Dear Editor,

I refer to the interesting study by Mohamed Abdelsalam et al.[1] published in April–June 2020 issue of the Libyan Journal of Medical Sciences. They reported extra intestinal manifestation (EIM) in 55.7% of Libyan patients with inflammatory bowel disease (IBD).[1] Its worthy to mention that it is still not obvious whether EIM is the aftermath of a shared genetic background resulting in disturbed functional immune responses to environmental stimuli or a direct consequence of the inflammatory process in the intestinal tract.[2] Worldwide, around one-third of IBD patients are affected by EIM.[3] The prevalence of EIM reported by Mohamed Abdelsalam et al.[1] was worryingly higher than that reported worldwide.[3] I presume that the following three factors could plausibly contribute to that difference in EIM prevalence.

First, there is a link between IBD severity and the risk to have EIM where sever disease is significantly associated with increased risk of EIM.[4]

Second, the duration of the IBD could influence EIM development. In general, after 10 years of IBD development, age at disease onset is not anymore correlated with disease behavior. Nevertheless, there is still a small difference in the evolution of EIM and complications.[5]

Third, the potential impacts of various environmental and genetic determinants related to Libyian population as well as unknown factors in aggravating the occurrence of EIM ought to be taken into consideration.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Mohamed Abdelsalam AE, Abdalla SI. A descriptive study of inflammatory bowel disease in eastern regions of Libya: A based survey of Benghazi's hospitals. Libyan J Med Sci 2020;4:72-5.  Back to cited text no. 1
  [Full text]  
2.
Ott C, Schölmerich J. Extraintestinal manifestations and complications in IBD. Nat Rev Gastroenterol Hepatol 2013;10:585-95.  Back to cited text no. 2
    
3.
Greuter T, Vavricka SR. Extraintestinal manifestations in inflammatory bowel disease-epidemiology, genetics, and pathogenesis. Expert Rev Gastroenterol Hepatol 2019;13:307-17.  Back to cited text no. 3
    
4.
Dotson JL, Hyams JS, Markowitz J, LeLeiko NS, Mack DR, Evans JS, et al. Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation to disease type and severity. J Pediatr Gastroenterol Nutr 2010;51:140-5.  Back to cited text no. 4
    
5.
Herzog D, Fournier N, Buehr P, Rueger V, Koller R, Heyland K, et al. Age at disease onset of inflammatory bowel disease is associated with later extraintestinal manifestations and complications. Eur J Gastroenterol Hepatol 2018;30:598-607.  Back to cited text no. 5
    




 

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