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ORIGINAL ARTICLE
Year : 2018  |  Volume : 2  |  Issue : 2  |  Page : 62-67

Pharmacovigilance for pediatric outpatient prescriptions in tripoli children hospital


1 Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya
2 Department of Anaesthesia and Intensive Care, Faculty of Medical Technology, University of Tripoli, Tripoli, Libya
3 Department of Orthodontic, Faculty of Dentistry, University of Tripoli, Tripoli, Libya

Correspondence Address:
Prof. Yousef A Taher
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Tripoli, Tripoli
Libya
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/LJMS.LJMS_3_18

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Background: Pharmacovigilance for pediatric drug therapy is lacking among Libyan patients. Hence, pediatric patients are at risk of unpredictable drug effects as a result of prescription fault. Therefore, this study was aimed to determine the drug prescribing errors for children attending the pediatric outpatient clinic at Tripoli Children Hospital, Libya. Materials and Methods: A retrospective study was carried out using the given prescription for patients who attended the hospital between July 2 and November 30, 2012. Patients aged below 13 years were included in the study. Drug use indicators were assessed using the British National Formulary guidelines. Results: There were 600 prescriptions (75.9%) collected for both, female patients (303 prescriptions, 50.5%) and male patients (297 prescriptions, 49.5%) with a total of 1167 prescribed drugs (on average 1.9 ± 1.2 items/prescription). Five hundred and eighty-six prescriptions are found which had at least one type of error, and this correlated with increased number of drugs per prescription. The error rate was 97.7%. Prescribing by inadequately dosing was done in 3.3% of all the prescribed medications, while 3.8% had inadequate durations. Furthermore, diagnosis, dosage, frequency, duration, and instruction were omitted in 96.5%, 5.7%, 10.2%, 42.8%, and 89.6% overall prescribed drugs, respectively. Drug–drug interactions were found in 63 prescriptions (10.5%) and involved mostly antiepileptic medications. Conclusion: Our study demonstrates that pediatric patients are at high risk of both, treatment failure, and adverse drug reactions. Hence, pharmacovigilance for pediatric prescriptions is critically needed. As well, a continuous medical education, in particular rational drug prescription, with much focus on the pediatric doctors, is strongly recommended.


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