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ORIGINAL ARTICLE
Year : 2020  |  Volume : 4  |  Issue : 1  |  Page : 21-24

Corrected estimated glomerular filtration rate is a predictor for survival in multiple myeloma patients


1 Department of Medicine, Tripoli Central Hospital, Tripoli University, Tripoli, Libya
2 Hematology Unit, Tripoli Children Hospital, Tripoli, Libya
3 Department of Oncology, Tripoli Medical Center, Tripoli, Libya
4 Department of Medicine, Tripoli Central Hospital, Tripoli, Libya
5 Medical Student, Tripoli University, Tripoli, Libya
6 Department of Internal Medicine, Alwakar Hospital, Doha, Qatar

Correspondence Address:
Prof. Elmukhtar Habas
Department of Medical, Tripoli Central Hospital, Tripoli
Libya
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/LJMS.LJMS_8_20

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Background/Aim: Kidneys' involvement in multiple myeloma (MM) adversely affects the prognosis. The aim of this study is to assess the relationship between corrected estimated glomerular filtration rate (corrected eGFR) and patients' survival during the first 1 year of follow-up. Methods: Thirty-eight patients with MM and renal impairment followed up from 2013 to 2014 were enrolled in this study. Data were collected and analyzed. Paired t-test and one-way ANOVA were used to compare means at presentation, after 6 months, and at 1 year. Results: There were 20 female (52.6%) and 18 male patients (47.4%) at presentation, aged between 43 and 92 years; their mean weight was 61.3 ± 1.9 kg, and mean body surface area was 1.53 ± 0.04 m2. The mean of blood urea, serum creatinine, and corrected eGFR at presentation was 65.5 ± 7.4 mg/dl, 2 ± 0.41 mg/dl, and 40.6 ± 4.5 ml/min/1.73 m2, respectively. After 6 months, only twenty patients were still alive (i.e., 13 females and 7 males, aged 68.2 ± 2 years), and their mean corrected eGFR was 67.8 ± 29.1 ml/min/1.73 m2. After 1 year, only nine patients (i.e., six females and three males) were alive and continued in follow-up; their mean corrected eGFR was 96.7 ± 10.3 ml/min/1.73 m2. Corrected eGFR mean was statistically significantly lower at presentation than that after 6 months (P = 0.002), whereas during 6 months, the mean corrected eGFR was statistically significantly lower than that after 1 year (P = 0.014), and patients lived a year of follow up, corrected eGFR was higher than at presentation (P = 0.003). The correlation between corrected eGFR and patients' survival at 6 months and 12 months showed that the lower the corrected eGFR, the higher the rate of patient death (P = 0.0001). Conclusion: Corrected eGFR is a good indicator for survival in renal impairment in MM patients during the 1st year of diagnosis.


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