|Year : 2020 | Volume
| Issue : 1 | Page : 21-24
Corrected estimated glomerular filtration rate is a predictor for survival in multiple myeloma patients
Elmukhtar Habas1, Abdulatif Khamaj1, Amnna Rayani2, Afaf Aboshala3, Ismail Siala3, Mohamed Tabib4, Ala Habas5, Kalifa Farfar6, Islam A Elzouki4
1 Department of Medicine, Tripoli Central Hospital, Tripoli University, Tripoli, Libya
2 Hematology Unit, Tripoli Children Hospital, Tripoli, Libya
3 Department of Oncology, Tripoli Medical Center, Tripoli, Libya
4 Department of Medicine, Tripoli Central Hospital, Tripoli, Libya
5 Medical Student, Tripoli University, Tripoli, Libya
6 Department of Internal Medicine, Alwakar Hospital, Doha, Qatar
|Date of Submission||07-Feb-2020|
|Date of Acceptance||18-Feb-2020|
|Date of Web Publication||12-Mar-2020|
Prof. Elmukhtar Habas
Department of Medical, Tripoli Central Hospital, Tripoli
Source of Support: None, Conflict of Interest: None
Background/Aim: Kidneys' involvement in multiple myeloma (MM) adversely affects the prognosis. The aim of this study is to assess the relationship between corrected estimated glomerular filtration rate (corrected eGFR) and patients' survival during the first 1 year of follow-up. Methods: Thirty-eight patients with MM and renal impairment followed up from 2013 to 2014 were enrolled in this study. Data were collected and analyzed. Paired t-test and one-way ANOVA were used to compare means at presentation, after 6 months, and at 1 year. Results: There were 20 female (52.6%) and 18 male patients (47.4%) at presentation, aged between 43 and 92 years; their mean weight was 61.3 ± 1.9 kg, and mean body surface area was 1.53 ± 0.04 m2. The mean of blood urea, serum creatinine, and corrected eGFR at presentation was 65.5 ± 7.4 mg/dl, 2 ± 0.41 mg/dl, and 40.6 ± 4.5 ml/min/1.73 m2, respectively. After 6 months, only twenty patients were still alive (i.e., 13 females and 7 males, aged 68.2 ± 2 years), and their mean corrected eGFR was 67.8 ± 29.1 ml/min/1.73 m2. After 1 year, only nine patients (i.e., six females and three males) were alive and continued in follow-up; their mean corrected eGFR was 96.7 ± 10.3 ml/min/1.73 m2. Corrected eGFR mean was statistically significantly lower at presentation than that after 6 months (P = 0.002), whereas during 6 months, the mean corrected eGFR was statistically significantly lower than that after 1 year (P = 0.014), and patients lived a year of follow up, corrected eGFR was higher than at presentation (P = 0.003). The correlation between corrected eGFR and patients' survival at 6 months and 12 months showed that the lower the corrected eGFR, the higher the rate of patient death (P = 0.0001). Conclusion: Corrected eGFR is a good indicator for survival in renal impairment in MM patients during the 1st year of diagnosis.
Keywords: Corrected estimated glomerular filtration rate, multiple myeloma, renal impairment, renal involvement, survival time
|How to cite this article:|
Habas E, Khamaj A, Rayani A, Aboshala A, Siala I, Tabib M, Habas A, Farfar K, Elzouki IA. Corrected estimated glomerular filtration rate is a predictor for survival in multiple myeloma patients. Libyan J Med Sci 2020;4:21-4
|How to cite this URL:|
Habas E, Khamaj A, Rayani A, Aboshala A, Siala I, Tabib M, Habas A, Farfar K, Elzouki IA. Corrected estimated glomerular filtration rate is a predictor for survival in multiple myeloma patients. Libyan J Med Sci [serial online] 2020 [cited 2020 May 29];4:21-4. Available from: http://www.ljmsonline.com/text.asp?2020/4/1/21/280571
| Introduction|| |
Multiple myeloma (MM) was described during the 18th century. It is a plasma cell malignancy and part of hematological disease spectrum ranging from monoclonal gammopathy of unknown significance to plasma cell leukemia. MM is suspected if bone marrow aspiration has ≥10% of clonal plasma cells or bone biopsy-proven plasmacytoma in addition to end-organ damage. Other workers consider that the presence of ≥60% of plasma cells in bone marrow aspiration even without end-organ damage is diagnostic for MM diagnosis. MM is due to an abnormal B-lymphocyte clonal disease of plasma cells, leading to increase of plasma cells in bone marrow and peripheral blood, producing an increase in monoclonal protein synthesis, lytic bone lesions, and renal insufficiency (RI). RI occurs in about 20%–40% of MM at presentation.,,, Creatinine clearance reduced in about 50% of newly diagnosed MM patients. Other studies reported that renal involvement had been detected in 15%–40% of MM patients. Approximately 30%–40% of MM patients had serum creatinine above 1.5 mg/100 ml, and most of the MM patients had serum creatinine <4 mg/dl at diagnosis.,,, Moreover, other studies conducted in different district hospitals reported that about 10% of MM patients presented with severe renal failure that required urgent hemodialysis., Others reported that RI was in 30%–50% when serum creatinine was ≥1.5 mg/dl in MM. Others considered serum creatinine ≥2 mg/dl as the upper limit of normal kidney function, then newly diagnosed MM patients had RI were about 20%.,,
The etiology of RI in MM is mainly due to monoclonal light chains' toxic effect on different nephron tissues. Amyloidosis, hypercalcemia, dehydration, drugs' toxic effects, and contrast nephropathy are common contributory risk factors for RI in MM. Renal function improves usually after good hydration, correction of hypercalcemia, and discontinuation of nephrotoxic drugs in most of the MM patients who have RI. Half of the MM patients who presented with RI recover during the first 6 weeks of presentation with good hydration. Later, recovery of renal function in MM patients is possible, and even regular long-term hemodialysis may be discontinued in some patients. Those patients who do not recapture the normal renal function will survive with mild or moderate RI. A study reported that only 1% of the MM patients developed end-stage renal disease and required long-term regular hemodialysis.
Normal corrected estimated glomerular filtration rate (eGFR) in a healthy human ranges between 90 and 130 mL/min/1.73 m2. Corrected eGFR affected by gender, muscle mass, and other factors increase or decrease serum creatinine concentration. Corrected eGFR is more precise for renal function assessment than serum creatinine and urea. Although technetium-99–labeled, diethylene-triamine-pentacetic acid; chromium-51–labeled ethylenediaminetetraacetic acid; and 125I-iothalamate are used, inulin is still the accurate method to measure glomerular filtration rate (GFR). In clinical practice, creatinine clearance is commonly used to assess GFR, although creatinine clearance gives higher GFR value by about 5%–10% of the actual GFR.,
Cockcroft–Gault and Modification of Diet in Renal Disease study equations are the most accurate used formulae to calculate eGFR in chronic kidney disease (CKD) patients., Other formulas, such as CKD epidemiology collaboration equation, serum cystatin-C, and urinary creatinine were used to calculate eGFR in MM patients. In acute RI, eGFR assessed by the above-mentioned methods was not accurate enough, and the RIFLE and Acute Renal Injury Network criteria are most appropriate to assess RI severity in this situation, although they need to be validated carefully especially in MM patients on chemotherapy.
To our knowledge, there is no study performed to assess the effectiveness of corrected eGFR on the prognosis of MM patients in Libya; therefore, this study was conducted.
| Methods|| |
Records of 129 MM patients were studied retrospectively. The patients were followed up in the Medical Department at Tripoli Central Hospital (TCH), Sabrata Oncology Center and Tripoli Medical Center. Out of these 129 patients, 38 patients had raised serum creatinine and urea and low corrected eGFR during a year of follow-up after MM diagnosis. Patients' gender, age, body weight, complete blood picture, blood urea, serum creatinine, and electrolytes were collected from their follow-up notes at presentation, after 6 months, and at 1 year of follow-up during 2013–2014. GFR was calculated by Cockcroft–Gault equation (creatinine clearance value = [140 − age] [weight (kg) × 0.85 if female]/[72 × Scr]), adjusted for individual body surface area (BSA). BSA was calculated by Mosteller method (BSA [m2] = square root of [height (cm) × weight (kg)]/3600). Corrected eGFR was calculated by (corrected eGFR = GFR × 1.73/BSA). The study was approved by the TCH Ethical and Scientific Committee.
Statistical analysis was conducted by IBM-SPSS (version 19.0, Chicago, IL, USA). Quantitative data were expressed as mean ± standard deviation and range (minimum, maximum). Paired Student's t-test and one-way ANOVA analysis were used to compare the mean differences of the parameters at presentation, after 6 months, and at 1 year from the diagnosis of MM. P < 0.05 was considered statistically significant.
| Results|| |
At the time of presentation of MM with RI, 38 patients' records were diagnosed and reviewed. They were 20 females (52.6%) and 18 males (47.4%). After 6 months of follow-up, twenty patients were alive and continued for follow-up. There were 13 females and 7 males. After 1 year of follow-up, only nine patients (six females and three males) were alive and continued follow-up. [Table 1] shows the demographic features and laboratory findings of these patients at the time of diagnosis and in the follow-up periods. The mean corrected eGFR improved over the time of follow-up; it was statistically significantly higher after 6 months and after 1 year than at presentation (P = 0.002 and P = 0.003, respectively). In addition, corrected eGFR after 6 months was lower than that in the 1-year follow-up period (P = 0.014). There was a statistically significant correlation between corrected eGFR and patients' survival after 6 months and 12 months; the lower the corrected eGFR, the higher the rate of patient death after 6 months and 1 year (P = 0001).
|Table 1: Demographic characteristics and laboratory results of multiple myeloma patients with renal impairment at the time of diagnosis, 6 months, and 1 year of follow-up|
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| Discussion|| |
Worldwide, MM consists of about 1% of the whole malignancies, and it accounts of about 10% of hematologic malignancies., In this study, 129 patients were diagnosed as MM in the main cancer centers in the western part of Libya. Population of this part of Libya was around 60% of the total Libyan population (i.e., around 6 million during the study period). Hence, it can be predicted that MM prevalence was about 3.6/100,000 in the western part of Libya. It was reported that MM was common in men than women, especially in African-Americans compared with Caucasians-Americans. There was a female predominance (2:1) when MM patients were diagnosed at the time of conducting this study.
In this study, RI was reported in about 30% of the MM patients studied (creatinine ≥2 mg/dl), but others reported higher frequency. The difference between this study reported result might be due to the lower serum creatinine used compared by the other previous studies.
Furthermore, in this study, they were 38 patients who had renal involvement by MM at the time of presentation. Eighteen patients died during the first 6 months, 16 of them had corrected eGFR ≤20 ml/min/1.73 m2, and two patients had corrected eGFR ranged from 20 to 25 ml/min/1.73 m2. Of the rest 20 patients, 11 patients had corrected eGFR ≤48 ml/min/1.73 m2 and died during the next 6 months. Only nine patients who had corrected eGFR of 96.68 ml/min/1.73 m2 stayed alive till the end of the 1st year of follow-up after diagnosis. It seems that MM patients who had lower corrected eGFR died earlier.
| Conclusion|| |
Corrected eGFR is a significant prognostic indicator for survival in MM patients with renal involvement.
The authors would like to acknowledge the help and assistance of nurses and administrative workers in the hospitals where the enrolled patients were treated.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
The study was conducted when Prof. Elmukhtar Habas worked at Medical Department, Tripoli Central Hospital, Tripoli, Libya.
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